How It Works: The Role of Ca-AKG in Metabolic Health & Cellular Function

Healthy aging is not just about the passage of time, it’s about how well your cells maintain their function as you grow older. At the core of this process is your body’s ability to produce energy, repair itself, and manage the natural stress of metabolism.

Calcium Alpha-Ketoglutarate (Ca-AKG) is a key molecule involved in the Krebs Cycle: the critical process your cells use to generate energy. Beyond fueling metabolism, Ca-AKG plays a role in supporting bone and muscle health, aiding cellular detoxification, and helping the body manage inflammation.

Why Ca-AKG Matters:

As we age, natural levels of alpha-ketoglutarate decline, which may impact how efficiently our cells produce energy and repair damage. This decline is linked to physical frailty, reduced muscle mass, and metabolic slowdown; factors that contribute to age-related decline in health.

By restoring this critical compound, Ca-AKG helps maintain core metabolic functions essential for healthspan supporting your body’s resilience, strength, and vitality.

What the Research Shows:

1. Central to Energy Production
   Ca-AKG fuels the Krebs Cycle, driving the process that generates ATP,  the energy your cells need to function optimally.
   
    
2. Supports Bone & Muscle Strength
   Essential for collagen synthesis, Ca-AKG helps maintain bone density and muscle integrity, key factors in staying strong and mobile with age.
   
    
3. Promotes Cellular Cleansing and Detoxification
   Ca-AKG plays a role in removing excess nitrogen and metabolic waste, supporting healthy cellular environments.
   
    
4. Helps Moderate Inflammatory Responses
   Research suggests Ca-AKG may help reduce markers of systemic inflammation, supporting healthier aging at the cellular level.
   
    

At DoNotAge.org, we don’t follow industry trends. We lead scientific discovery. Our Ca-AKG is trusted and used by researchers in clinical settings exploring how this molecule supports better health outcomes and preserves metabolic function over time. It’s also publicly backed by Dr. Nick Engerer, a longevity expert, researcher, and member of the DoNotAge.org advisory board. He considers Ca-AKG a foundational part of his personal healthspan protocol.

BENEFITS OF PURE Ca-AKG

✔ Supports Energy Metabolism — Fuels cellular processes essential for sustained energy production

 ✔ Promotes Bone and Muscle Health — Contributes to skeletal strength and muscle maintenance as you age

✔ Optimises Metabolic Function — Plays a critical role in amino acid metabolism and nutrient utilisation

✔ Encourages Healthy Cellular Function — Helps protect cells from metabolic stress and supports detoxification pathways

✔ Supports DNA and Cellular Maintenance — Aids natural repair mechanisms essential for healthy aging

✔ Helps Moderate Inflammatory Response — Supports the body’s ability to manage oxidative stress and maintain resilience

PRODUCT DETAILS

✔ Pure Calcium Alpha-Ketoglutarate (Ca-AKG) — Selected for its essential role in metabolic and cellular health

✔ No Fillers. No Additives. No Compromises — Just the ingredient used by researchers in clinical studies

✔ Formulated for Bioavailability — Easily mixed into water or your preferred beverage for effective absorption

✔ Vegan, Non-GMO, and Allergen-Free — Free from synthetic ingredients, preservatives, or animal derivatives

✔ Third-Party Lab Verified — Every batch tested to meet the highest standards for purity and safety

At DoNotAge.org we prioritise health over hype, delivering ingredients used in global research, not just marketed as supplements

Calcium Alpha-Ketoglutarate (Ca-AKG) – Core Support for Energy, Recovery, and Cellular Health

At DoNotAge.org, we don’t follow industry trends, we lead global health research. Our Ca-AKG is used by scientists in clinical trials because it meets the purity, consistency, and performance standards required for serious scientific application.

Ca-AKG is a molecule your body naturally produces. It plays a central role in energy metabolism, supports detoxification, and helps maintain structural integrity in muscles and bones. But levels drop significantly with age, which can contribute to fatigue, physical decline, and impaired cellular repair.

Clinical research has shown that restoring AKG levels may support:

✔ Cellular Energy – Fuels the Krebs cycle to power your cells and support metabolic vitality*
✔ Muscle & Bone Health – Helps maintain strength and resilience through collagen and protein synthesis*
✔ Inflammation Management – Supports a healthier immune response and lowers cellular stress markers*
✔ Detoxification – Aids in clearing ammonia and metabolic byproducts to protect cellular function*
✔ Healthy Aging – Contributes to DNA stability and long-term cellular maintenance*

At DoNotAge.org, our Ca-AKG is not a generic supplement. It’s a research-leading ingredient actively used by experts investigating how to extend healthspan and improve age-related outcomes. Every batch is tested in-house and independently verified, with no unnecessary fillers or additives.

This is real science not marketing. Just clinically relevant Ca-AKG, delivered with the integrity you expect from a Health Research Organisation.

Pure Ca-AKG Capsules – Clean, Clinically Tested Form

Each capsule delivers pure calcium alpha-ketoglutarate, formulated with precision and care. Used by health researchers and trusted in clinical settings, our Ca-AKG is encapsulated without fillers or unnecessary additives, just the ingredient your body needs, delivered in a clean and convenient format.

✔ Non-GMO and Allergen-Free – Free from preservatives, synthetic fillers, and common allergens*
✔ Easy-to-Take Capsules – Precisely dosed for consistency and convenience*
✔ Vegan and Clean – Plant-based capsules made without gelatin or animal byproducts*
✔ Gentle on Digestion – Designed for everyday use, even for those with sensitivities*
✔ Independently Tested – Verified for purity, identity, and consistency in every batch*

At DoNotAge.org, we provide Ca-AKG that meets the standards required by leading health researchers with full transparency, no shortcuts, and no compromises.

The DoNotAge.org Quality Guarantee

This product comes with the DoNotAge.org Quality Guarantee. We proudly guarantee purity and quality from our facility to your home, no matter where you live.

✔ Produced to GMP and ISO9001 Standards – Ensuring the highest levels of manufacturing excellence.*
✔ Science-Led & Rigorously Tested – Formulated for superior effectiveness and safety.*
✔ Full Instructions Included – Your order comes with easy-to-follow guidelines for optimal results.*
✔ 100% Vegan & Clean – Free from unnecessary additives, making it suitable for all dietary preferences.*

At DoNotAge.org, we are committed to delivering science-leading solutions that empower people to live longer, healthier lives. Ca-AKG is part of our greater mission to advance longevity research and make cutting-edge breakthroughs accessible to all.